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KMID : 0043319950180020129
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Archives of Pharmacal Research
1995 Volume.18 No. 2 p.129 ~ p.132
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O-Acetyljervine;A New β-adrenoceptor agonist from veratrum album
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Gilani Anwar-H.
Khalid-Aftab
S.A. Saeed
Rahat-A. Ali
Rahman, Atta-ur
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Abstract
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Intravenous administration of O-acetyliervine (an alkaloid from Vertrum album) produced a dose-dependent (10-100 .mu.g/kg) fall in blood pressure and tachycardia in anaesthetized normotensive rats. Pretreatment of animals with propranolol (1mg/kg) abolished these cardiovascular responses of O-acetyljervine similar to that of isoprenaline . In isolated tissue experiments, O-acetyljervine produced a dose-dependent relaxation of phenylephrine-induced contraction of the rabbit aorta. In guinea-pig spontaneously beating atria, it caused positive inotropic and chronotorpic responses in a dose-dependent fashion . These responses were abolished in the presence of propranolol similar to that of isoprenaline. These results indicate that O-accetyljervine is adrenoceptor stimulant like isoprenaline.
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KEYWORD
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O-acetyljervine, Veratrum album, β-adrenoceptor agonist, Hypotensive, Cardiac stimulant
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